Harry L Malech Selected Research

Chronic Granulomatous Disease

4/2022	Febrile neutropenia management and outcomes in hematopoietic cell transplantation for chronic granulomatous disease.
1/2022	Granulocyte Transfusions in Patients with Chronic Granulomatous Disease Undergoing Hematopoietic Cell Transplantation or Gene Therapy.
1/2022	Safety and Efficacy of Ustekinumab in the Inflammatory Bowel Disease of Chronic Granulomatous Disease.
4/2021	Homozygous variant p. Arg90His in NCF1 is associated with early-onset Interferonopathy: a case report.
3/2021	Granulibacter bethesdensis, a Pathogen from Patients with Chronic Granulomatous Disease, Produces a Penta-Acylated Hypostimulatory Glycero-D-talo-oct-2-ulosonic Acid-Lipid A Glycolipid (Ko-Lipid A).
2/2021	Low Plasma Gelsolin Concentrations in Chronic Granulomatous Disease.
1/2021	Correction of X-CGD patient HSPCs by targeted CYBB cDNA insertion using CRISPR/Cas9 with 53BP1 inhibition for enhanced homology-directed repair.
1/2021	Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells.
12/2020	NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease.
10/2020	The response to vedolizumab in chronic granulomatous disease-related inflammatory bowel disease.

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Harry L Malech Research Topics

Disease

55	Chronic Granulomatous Disease 04/2022 - 03/2002
20	Infections 04/2022 - 03/2003
9	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 10/2020 - 07/2002
7	Neoplasms (Cancer) 01/2021 - 04/2003
7	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2020 - 02/2010
6	Mycoses (Diseases, Fungus) 01/2022 - 06/2003
6	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 10/2021 - 06/2007
6	WHIM syndrome 02/2015 - 10/2010
5	Inflammation (Inflammations) 01/2017 - 09/2010
5	Reinfection 04/2015 - 03/2003
4	Bacterial Infections (Bacterial Infection) 04/2022 - 06/2003
4	Liver Abscess 01/2018 - 03/2007
3	Neutropenia 04/2022 - 10/2010
3	Cytopenia 01/2022 - 04/2014
3	Primary Immunodeficiency Diseases 01/2020 - 02/2014
3	Autoimmune Diseases (Autoimmune Disease) 01/2017 - 01/2007
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2017 - 05/2013
3	Colitis 06/2015 - 01/2011
3	Granuloma 08/2013 - 06/2006
2	Fever (Fevers) 04/2022 - 04/2021
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 10/2020
2	Severe combined immunodeficiency due to adenosine deaminase deficiency 10/2021 - 01/2021
2	Epstein-Barr Virus Infections 01/2021 - 01/2020
2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 01/2020 - 01/2009
2	Abscess 01/2018 - 06/2008
2	Crohn Disease (Crohn's Disease) 06/2014 - 01/2011
2	Warts (Wart) 04/2014 - 01/2007
2	Weight Loss (Weight Reduction) 01/2013 - 02/2010
2	Acute Erythroblastic Leukemia (Erythroleukemia) 01/2007 - 04/2005
1	Febrile Neutropenia 04/2022
1	Hypersensitivity (Allergy) 01/2022
1	Sarcoma (Soft Tissue Sarcoma) 10/2021
1	Headache (Headaches) 04/2021
1	Virus Diseases (Viral Diseases) 01/2021
1	Sickle Cell Anemia (Hemoglobin S Disease) 01/2021
1	Idiopathic CD4-Positive T-Lymphocytopenia (T Lymphocytopenia, Idiopathic CD4 Positive) 01/2020
1	Lymphadenopathy 01/2020
1	Dysgammaglobulinemia 01/2020

Drug/Important Bio-Agent (IBA)

18	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2022 - 07/2002
14	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 12/2002
10	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2021 - 12/2010
9	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 01/2019 - 12/2002
8	NADP (NADPH)IBA 12/2020 - 06/2006
8	Superoxides (Superoxide)IBA 12/2016 - 07/2003
7	Anti-Bacterial Agents (Antibiotics)IBA 04/2022 - 03/2003
7	Chemokine ReceptorsIBA 02/2015 - 01/2007
5	AntibodiesIBA 01/2022 - 07/2005
4	Immunoglobulin G (IgG)IBA 06/2014 - 06/2008
4	plerixafor FDA Link 04/2014 - 10/2010
4	Interferon-gamma (Interferon, gamma)IBA 09/2004 - 08/2002
3	Messenger RNA (mRNA)IBA 01/2022 - 12/2020
3	Busulfan (Busulfex)FDA Link 10/2021 - 01/2010
3	Adenosine DeaminaseIBA 10/2021 - 04/2003
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018 - 05/2004
3	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 02/2015 - 06/2007
2	GlobinsIBA 01/2022 - 01/2021
2	MagnesiumIBA 01/2021 - 01/2020
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2019
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2020 - 01/2020
2	Glycoproteins (Glycoprotein)IBA 01/2020 - 12/2010
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 12/2014
2	EnzymesIBA 01/2019 - 01/2015
2	neutrophil cytosol factor 40KIBA 01/2018 - 12/2010
2	CytokinesIBA 01/2017 - 10/2007
2	Codon (Codons)IBA 01/2016 - 10/2007
2	Immunoglobulin A (IgA)IBA 06/2014 - 01/2011
2	Immunoglobulins (Immunoglobulin)IBA 04/2014 - 08/2013
2	VaccinesIBA 04/2014 - 04/2014
2	ATL 146eIBA 01/2013 - 02/2010
2	Adenosine (Adenocard)FDA LinkGeneric 01/2013 - 02/2010
2	CalciumIBA 07/2012 - 04/2005
2	Cytokine Receptors (Cytokine Receptor)IBA 11/2008 - 07/2002
2	InterleukinsIBA 11/2008 - 07/2007
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 09/2004 - 06/2003
1	Carbapenems (Carbapenem Antibiotics)IBA 04/2022
1	Alemtuzumab (Campath)FDA Link 04/2022
1	Ustekinumab (CNTO 1275)FDA Link 01/2022
1	RNA Splice SitesIBA 01/2022
1	SteroidsIBA 04/2021
1	Janus Kinase InhibitorsIBA 04/2021
1	tofacitinibIBA 04/2021
1	Ferritins (Ferritin)IBA 04/2021
1	AcidsIBA 03/2021
1	Lipid AIBA 03/2021
1	GlycolipidsIBA 03/2021
1	PENTAIBA 03/2021
1	GelsolinIBA 02/2021
1	vedolizumabIBA 10/2020
1	Sirolimus (Rapamycin)FDA Link 01/2020
1	Pentostatin (Nipent)FDA LinkGeneric 01/2020

Therapy/Procedure

16	Therapeutics 04/2022 - 03/2003
11	Transplantation 04/2022 - 05/2004
8	Hematopoietic Stem Cell Transplantation 10/2021 - 01/2006
4	Cell Transplantation 04/2022 - 10/2018
3	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2020 - 07/2002
3	Salvage Therapy 01/2012 - 06/2005
2	Blood Component Removal (Apheresis) 12/2020 - 02/2015
2	Drug Therapy (Chemotherapy) 01/2019 - 01/2017
1	Enzyme Replacement Therapy 10/2021
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2021